Presure settings have nothing to do with keg size so the answer to question to is yes. On question one I wouldnt know as I don't use a tower, but from what I have read and heard I would make sure whatever you use make sure you still have good air flow into the tower to cool it.
Semper Fi,
The Gunns
"Beer is proof that god loves us and wants us to be happy" - Benjamin Franklin
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