You need to check and see if this kegerator comes with a 'stout faucet'.
Granted, I don't have a nitro set up, but I think you need the faucet as well at the nitro in order to get the guinness effect.
If you do have the stout faucet, I belive you can remove this little disc and it will function just like any other faucet.
Don't quote me on this, but I think you can fill your tank with straight Co2. As long as the regulator fits the tank (which I assume it does since the previous guy was using it) it should be ok. It might be better to take it up to where you will get it filled and ask them.
as for using the mix on all beers, If you have the stout faucet, I have heard people trying out other beers and getting the Guinness effect (cascading head) with ales and what not.
Nitrogen is not nearly as soluble in liquid as Co2 and comes out solution a lot more quickly. If the mix gas is more expensive, I definately would not use it for everyday/every beer carbing.
Not sure what type of beer you will be primarily serving, but if it is mostly domestic light beer, just fill the tank with reg Co2 and go from there.